Jennifer Chen, MD

Education
06/2016 - Fellowship in Gastroenterology and Hepatology, Massachusetts General Hospital
06/2012 - Residency in Internal Medicine, Brigham and Women's Hospital
MD, 06/2009 - Doctor of Medicine, Harvard Medical School
AB, 06/2003 - Government, Harvard College
Websites
Publications

  1. Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY. Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis. Frontiers in medicine 2022. PMID: 36275798


  2. Zhang P, Li X, Chen JY, Abate AR. Controlled fabrication of functional liver spheroids with microfluidic flow cytometric printing. Biofabrication 2022. PMID: 35917810


  3. Li W, Chen JY, Sun C, Sparks RP, Pantano L, Rahman RU, Moran SP, Pondick JV, Kirchner R, Wrobel D, Bieler M, Sauer A, Ho Sui SJ, Doerner JF, Rippmann JF, Mullen AC. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. eLife 2022. PMID: 35617485


  4. Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Science translational medicine 2020. PMID: 32817366


  5. Chen JY, Ren Y, Yan P, Belina ME, Chung RT, Butt AA. Tricyclic antidepressant use and the risk of fibrosis progression in hepatitis C-infected persons: Results from ERCHIVES. Journal of viral hepatitis 2018. PMID: 29478294


  6. Caniglia EC, Zash R, Jacobson DL, Diseko M, Mayondi G, Lockman S, Chen JY, Mmalane M, Makhema J, Hernán MA, Shapiro RL. Emulating a target trial of antiretroviral therapy regimens started before conception and risk of adverse birth outcomes. AIDS (London, England) 2018. PMID: 29112066


  7. Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York SR, Motola DL, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev EV, Fuchs BC, Hannun Y, Chung RT, Mullen AC. Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Scientific Reports 2017. PMID: 28322247


  8. Zash R, Souda S, Chen JY, Binda K, Dryden-Peterson S, Lockman S, Mmalane M, Makhema J, Essex M, Shapiro R. Reassuring Birth Outcomes With Tenofovir/Emtricitabine/Efavirenz Used for Prevention of Mother-to-Child Transmission of HIV in Botswana. Journal of acquired immune deficiency syndromes (1999) 2016. PMID: 26379069


  9. Zhou C, York SR, Chen JY, Pondick JV, Motola DL, Chung RT, Mullen AC. Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins. Genome medicine 2016. PMID: 27007663


  10. Dryden-Peterson S, Lockman S, Zash R, Lei Q, Chen JY, Souda S, Petlo C, Dintwa E, Lebelonyane R, Mmalane M, Shapiro RL. Initial programmatic implementation of WHO option B in Botswana associated with increased projected MTCT. Journal of acquired immune deficiency syndromes (1999) 2015. PMID: 25501611


  11. Kelly P, Saloojee H, Chen JY, Chung RT. Noncommunicable diseases in HIV infection in low- and middle-income countries: gastrointestinal, hepatic, and nutritional aspects. Journal of acquired immune deficiency syndromes (1999) 2014. PMID: 25117963


  12. Chen JY, Feeney ER, Chung RT. HCV and HIV co-infection: mechanisms and management. Nature reviews. Gastroenterology & hepatology 2014. PMID: 24535328


  13. Chen JY, Chung RT. Future classes of hepatitis C virus therapeutic agents. Infectious disease clinics of North America 2012. PMID: 23083826


  14. Chen JY, Ribaudo HJ, Souda S, Parekh N, Ogwu A, Lockman S, Powis K, Dryden-Peterson S, Creek T, Jimbo W, Madidimalo T, Makhema J, Essex M, Shapiro RL. Highly active antiretroviral therapy and adverse birth outcomes among HIV-infected women in Botswana. The Journal of infectious diseases 2012. PMID: 23066160


  15. Chung RT, Umbleja T, Chen JY, Andersen JW, Butt AA, Sherman KE. Extended therapy with pegylated interferon and weight-based ribavirin for HCV-HIV coinfected patients. HIV clinical trials 2012. PMID: 22510354


  16. Matthews LT, Ribaudo HJ, Parekh NK, Chen JY, Binda K, Ogwu A, Makhema J, Souda S, Lockman S, Essex M, Shapiro RL. Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S.-born black infants. BMC pediatrics 2011. PMID: 22176889


  17. Zhang Y, Lu L, Li HQ, Liu W, Tang ZR, Fang H, Chen JY, Ma Y, Zhao Y, Chen RY, Zhang FJ. Engaging HIV-infected patients in antiretroviral therapy services: CD4 cell count testing after HIV diagnosis from 2005 to 2009 in Yunnan and Guangxi, China. Chinese medical journal 2011. PMID: 21740803


  18. Chen JY, Chung RT. Can we use the "C" word with confidence? Cure for chronic hepatitis C. Gastroenterology 2011. PMID: 21256845


  19. Chen JY, Ogwu AC, Svab P, Lockman S, Moffat HJ, Gaolathe T, Moilwa S, Størdal K, Dryden-Peterson S, Moffat C, Makhema J, Essex M, Shapiro RL. Antiretroviral treatment initiation among HIV-infected pregnant women with low CD4(+) cell counts in Gaborone, Botswana. Journal of acquired immune deficiency syndromes (1999) 2010. PMID: 19864957


  20. Belkora JK, Loth MK, Chen DF, Chen JY, Volz S, Esserman LJ. Monitoring the implementation of Consultation Planning, Recording, and Summarizing in a breast care center. Patient education and counseling 2008. PMID: 18755564